The additional material includes a new Background section, intended to provide a broad overview of breast cancer for non-clinicians; a new Topic 1, Primary care and the management of women at high risk; and a new Topic 8, Management of advanced, recurrent and metastatic disease. The topic areas and numbers therefore differ from the original Manual. Material in the Evidence sections of the topic areas is based on systematic reviews of research evidence carried out by the NHS Centre for Reviews and Dissemination. The Research Evidence for the Manual Update provides a summary of these systematic reviews. It is available on the accompanying CD-rom or to purchase as.
