We do not yet know what causes most cases of endometrial cancer. But we do know that certain risk factors are linked to this disease. A risk factor is anything that changes a person's chance of getting a disease such as cancer. Different cancers have different risk factors. For example, being in strong sunlight without protection is a risk factor for skin cancer. Smoking is a risk factor for many cancers. Some risk factors, like your age or race, can't be changed. Others, like smoking and diet are under your control. But risk factors don't tell us everything. Someone.