Estrogen therapy: Using estrogen to treat symptoms of change of life is known as estrogen therapy or menopausal hormone therapy. Estrogen treatment can reduce hot flashes, improve vaginal dryness, and help prevent the weakening of the bones (osteoporosis) that can happen with menopause. But the use of estrogen by itself increases a woman's risk of getting endometrial cancer in women who still have a uterus. Estrogen therapy also increases a woman's chance of developing serious blood clots and heart disease. Studies show that giving progesterone-type drugs along with the estrogens helps lower the risk of endometrial cancer. But studies also.