Tamoxifen: Tamoxifen is a drug that is used to treat women with breast cancer. It is also used to reduce the risk in women who are at a high risk of getting breast cancer. The drug acts like estrogen in the uterus. It can cause the uterine lining to grow and increase the risk of endometrial cancer. The risk of getting endometrial cancer in women taking tamoxifen is fairly small (about 1 in 500). It must be balanced against the value of this drug in treating and preventing breast cancer. This is something women may want to talk about with.