A: high-fat diet can increase the risk of many cancers, including endometrial cancer. Because fatty foods are also high-calorie foods, a high-fat diet can lead to obesity, which is also an endometrial cancer risk factor. Some doctors think that fatty foods may have a direct effect on estrogen levels, which can increase risk, too. Exercise protects against endometrial cancer. Studies found that women who exercised more had a lower risk of this cancer, while one study showed that women who spent more time sitting had a higher risk
