Although most cases of endometrial cancer cannot be prevented, there are some things that may lower your risk of getting this disease. One thing you can do is to change risk factors whenever possible. Women who are overweight or obese have up to 3½ times the risk of getting endometrial cancer as compared to women with a healthy weight. Getting to and maintaining a healthy weight is one way to lower the risk of this cancer. Regular physical activity (exercise) may also be a way to help lower endometrial cancer risk. Estrogen to treat the symptoms of.