Getting treatment of an endometrium problem before it becomes cancer is another way to lower the risk of endometrial cancer. Most endometrial cancers develop over many years. Many are known to follow, and maybe start from, less serious problems of the lining of the uterus, such as increased growth of this lining (hyperplasia). Some cases of hyperplasia will go away without treatment. But sometimes it needs to be treated with hormones or even surgery. Treatment can prevent hyperplasia from becoming cancer. Women with hereditary nonpolyposis colon cancer (HNPCC, Lynch syndrome) have a very high risk of endometrial cancer. A.