Endometrial biopsy: This kind of biopsy can be done in a doctor's office. A very thin flexible tube is placed into the uterus through the cervix. Then suction is used to remove a small amount of endometrium. The suction usually takes less than a minute. The discomfort is much thing like menstrual cramps and can be helped by taking a drug like ibuprofen before the test. Sometimes numbing medicine is put into the cervix just before the test to help reduce the pain. Ultrasound (see below) is often done before the biopsy. This helps the doctor find any suspicious areas.