This article offers a brief overview of the health evidence on Agent Orange and cancer, to help clinicians serve Vietnam veteran patients and their family members. The evidence comes from several sources including studies of Vietnam veterans, workers exposed to herbicides or dioxins (since dioxins contaminated the herbicide mixtures used in Vietnam) in occupational settings, and studies of health effects among Vietnamese populations in the aftermath of the war. This article does not offer a complete review of all these lines of evidence. Instead, it summarizes the evidence briefly, and introduces readers to benefits programs and other issues that arise in caring for cancer patients or.