We first highlight psychological and psychosocial issues associated with breast can- cer, and then underscore specific psychosocial variables that may play a role in the dis- ease. Further, we bring to light the current literature of psychosocial interventions for patients with cancer. We then introduce preliminary research from an on-going study funded by the National Cancer Institute (NCI). This is a pilot study intended to explore psychosocial factors and quality of life, preparatory to embarking on a larger scale, long- term study. Finally, we discuss clinical implications in an attempt to lend greater under- standing to the complexities surrounding the relationship between quality of life and psychosocial issues.