A complete screening medical examination for tuberculosis consists of a medical history, physical examination, chest radiography (CXR, when required), determination of immune response to Mycobacterium tuberculosis antigens (., tuberculin skin testing [TST] or interferon gamma release assay [IGRA], when required), and sputum testing for M. tuberculosis (when required, Figures 1 and 2). Applicants ≥15 years of age require a medical history, physical examination, and CXR. If an applicant has a CXR with findings suggestive of tuberculosis (page 5), has signs and symptoms of tuberculosis (page 5), or has human immunodeficiency virus (HIV) infection, the applicant should provide three sputum specimens to.