With the wisdom of hindsight, many of life's most consequential decisions are often a matter of happenstance. In the spring of 1965,1 was in Washington, DC, completing my second year as a Clinical Associate of the National Institute of Mental Health before I was to return to Boston for a planned career in academic psychiatry, when a friend from medical school approached me to discuss "an unusual job opportunity." Despite having secured a position on the faculty of Harvard Medical School, I could not resist this provocative invitation
