The Science as an open enterprise report highlights the need to grapple with the huge deluge of data created by modern technologies in order to preserve the principle of openness and to exploit data in ways that have the potential to create a second open science revolution. Exploring massive amounts of data using modern digital technologies has enormous potential for science and its application in public policy and business. The report maps out the changes that are required by scientists, their institutions and those that fund and support science if this potential is to be realised