We define and study an algebra Ψ∞ (M0 ) of pseudodifferential opera1,0,V tors canonically associated to a noncompact, Riemannian manifold M0 whose geometry at infinity is described by a Lie algebra of vector fields V on a compactification M of M0 to a compact manifold with corners. We show that the basic properties of the usual algebra of pseudodifferential operators on a compact manifold extend to Ψ∞ (M0 ).