We obtain global well-posedness, scattering, and global L10 spacetime t,x bounds for energy-class solutions to the quintic defocusing Schr¨dinger equao tion in R1+3 , which is energy-critical. In particular, this establishes global existence of classical solutions. Our work extends the results of Bourgain [4] and Grillakis [20], which handled the radial case.