Adrenocortical carcinoma (ACC) is a disease that most physicians, including many endocrinologists, will rarely, if ever, diagnose or let alone treat during the course of their medical practice. Medical textbooks of endocrinology and oncology rarely dedicate an entire chapter to this disease entity. The pursuit of research and clinical excellence in uncommon diseases is extremely challenging because of a lack of research prioritization, nonexistent treatment guidelines and overall paucity of coordination between researchers and physicians. ACC is one such disease where no infrastructure for a unified research agenda and no consensus treatment guidelines had been developed
