Neuro-ophthalmology is a subspecialty of neurology and ophthalmology that bridges the gap between eye and brain. This issue of Neurologic Clinics describes the key features and latest information on topics in neuro-ophthalmology of interest to practicing neurologists and, in particular, highlights areas for which referral might be reasonable to neuro-ophthalmologists. A quick review of the table of contents for this issue illustrates the depth and breadth of the neurologic topics that fall within neuro-ophthalmology. These include multiple sclerosis, orbital diseases, optic nerve disorders, vascular disorders, neuroophthalmic imaging, and ocular motility deficits. We hope that the readers enjoy this issue and are able to recognize, triage, manage, or refer these.