Advances in stem cell biology and biomaterials development in the late 1990s have helped drive on an ever expanding body of research in the field of tissue engineering and regenerative medicine. Scientists realized that the key to future success of functional tissues is bridging the gap between developmental biology and tissue engineering. We are all amazed by the high degree of sophistication and miniaturization found in nature. Nature is, indeed, a school of science. While tissue engineering and regenerative medicine inspired research and applications in areas like bone, cartilage and skin, it challenges the building of completely artificial organs, ., liver. The urgency of clinical emergencies drove.