Paradoxically, skin is both a primary barrier to systemic absorption of topically exposed chemicals and a portal to systemic delivery of transdermal medicaments. Knowledge of the factors that determine both extent and rate of chemical flux across the skin is an important component of both toxicology and pharmacology studies. The aim of this book is to provide current approaches and techniques by which dermal absorption may be quantitated utilizing end points relative to these two disciplines. There are a number of different experimental methods and mathematical modeling approaches in use today. Most are rooted in disciplines outside toxicology, yet their methods are applied to dermal absorption. This book.
