The Institute of Medicine convened the Clinical Research Roundtable (CRR) in early 2000 to provide a forum for stakeholders to discuss approaches to resolving both acute and long-term issues affecting the Clinical Research Enterprise. It strives to enhance mutual understanding of clinical research between the scientific community and the general public, while improving the public’s understanding of and participation in clinical studies. The stakeholders involved in the CRR include individuals from the academic health community, federal agencies sponsoring and regulating clinical research, private-sector sponsors of clinical research, foundations, public- and private-sector insurance programs, health plans and insurance companies, corporate purchasers of health care, and representatives of patient interests