The current extraordinary advances in basic biomedical and social sciences have unprecedented potential to improve the human condition. These insights, together with the human genome project and its successor proteomics, will require an enormous commitment to translational research to harvest their applications for medicine and public health. The progress in political and social theory, linguistics, statistics, psychology, and behavioral sciences generally deserves a similarly broad application of human research to reach full expression. These endeavors will require individuals to accept possible risk to themselves, benefiting the greater good with uncertain (or no) benefit accrued in return. Thus, those performing and overseeing research are obligated to provide the most reasonable assurances of.