The detailed characterization of the function of leucine-rich repeat kinase 2 (LRRK2) may provide insight into the molecular basis of neurodegenera-tion in Parkinson’s disease (PD) because mutations in LRRK2 cause a phe-notype with strong overlap to typical late-onset disease and LRRK2 mutations are responsible for significant proportions of PD in some popu-lations.