Herpes simplex virus type-1 and type-2 are highly prevalent human patho-gens causing life-long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This ini-tial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors, leading to penetration of the viral nucleocapsid and tegument proteins into the cytoplasm.