Human MOK2 is a DNA-binding transcriptional repressor. Previously, we identified nuclear lamin A⁄C proteins as protein partners of hsMOK2. Fur-thermore, we found that a fraction of hsMOK2 protein was associated with the nuclear matrix. We therefore suggested that hsMOK2 interactions with lamin A⁄C and the nuclear matrix may be important for its ability to repress transcription.