The bradykinin B2 receptor is coupled to G protein Gq⁄ 11 and becomes sequestered into intracellular compartments after activation. To more clo-sely define the receptor sequences involved in these processes and their functions, we systematically mutated all three intracellular loops (ICLs), either as point mutations or in groups of three to five amino acids to Ala, obtaining a total of 14 mutants.