Expanding coverage and improving the quality of HIV prevention, diagnosis, treatment and care interventions are required to achieve global goals and targets. HIV incidence is falling in many countries, but is increasing in others. National HIV responses must target high-quality, evidence-based HIV-specific prevention interventions to where transmission is actually occurring, and focus efforts on key populations underserved by current HIV programmes. Section below on the prevention revolution outlines how the health sector can capitalize on recent advances in reducing infections through combining and targeting preventive interventions for maximum impact. Improved integration of HIV and non-HIV health services, radical decentralization.