These changes in the WHO institutional framework, associated with the new aspects of public health challenges and other recent major technical developments, as well as the ongoing WCO re-profiling exercises, have generated the need for developing a second generation Country Cooperation Strategy (CCS). Mozambique’s second generation CCS, covering the period 2009– 2013, builds upon the first CCS that spanned the period 2004–2008. It incorporates national, regional and global developments in health that have occurred since the first generation CCS was formulated. It reflects the WHO values, principles and regional strategies for providing better support for addressing the health needs of Mozambique