Sodium 2-propenyl thiosulfate, a water-soluble organo-sulfane sulfur com-pound isolated from garlic, induces apoptosis in a number of cancer cells. The molecular mechanism of action of sodium 2-propenyl thiosulfate has not been completely clarified. In this work we investigated, byin vivo and in vitro experiments, the effects of this compound on the expression and activity of rhodanese.