Streptomyces coelicolorandStreptomyces pilosusproduce desferrioxamine siderophores which are encoded by thedesABCDgene . pilosusis used for the production of desferrioxamine B which is utilized in human medicine. We report the deletion of thedesA gene encoding a lysine decarboxylase in Streptomyces coelicolorA3(2).