Presenilins are required for the function of c-secretase: a multiprotein complex implicated in the development of Alzheimer’s disease (AD). We analyzed expression of the presenilin 1 (PS1) gene. We show that ERM recognizes avian erythroblastosis virus E26 oncogene homolog (Ets) motifs on the PS1 promoter located at)10, +90, +129 and +165, and activates PS1 transcription with promoter fragments containing or not the)10 Ets site.