Synaptic targeting of GluR-A subunit-containing glutamate receptors involves an interaction with synapse-associated protein 97 (SAP97). The C-terminus of GluR-A, which contains a class I PDZ ligand motif (-x-Ser⁄Thr-x-/-COOH where /is an aliphatic amino acid) associates preferentially with the second PDZ domain of SAP97 (SAP97PDZ2).