The anticancer agents cisplatin and oxaliplatin are widely used in the treat-ment of human neoplasias. A genome-wide screen inSaccharomyces cere-visiae previously identified PPH3and PSY2among the top 20 genes conferring resistance to these anticancer agents. The mammalian ortho-logue of Pph3p is the protein serine⁄threonine phosphatase Ppp4c, which is found in high molecular mass complexes bound to a regulatory subunit R2.