Estrogen is known to influence glucose homeostasis but the role of estrogen receptors in muscle glucose metabolism is unknown. Therefore, we investigated the expression of the two estrogen receptors, ERa and ERb and their influence on regulation of GLUT4, and its associated structural protein, caveolin-1, in mouse muscle. ERaand ERbare co-expressed in the nuclei of most muscle cells and their levels were not affected by absence of estradiol (in aromatase knockout, ArKO, mice).
