In 2007, the National Research Council (NRC) released a report titled Toxicity Testing in the 21st Century: A Vision and a Strategy. That report pro- posed a new paradigm for toxicity testing that envisioned evaluation of biologi- cally significant perturbations in key toxicity pathways by using new methods in molecular biology, bioinformatics, and computational toxicology and a compre- hensive array of in vitro tests based primarily on human biology. The revolution in toxicity testing is under way, and a large influx of new data is anticipated. The . Environmental Protection Agency will need to be able to interpret the new data and.
