ProDom(Corpet et al., 2000) is one of the earliest clustered protein family databases and continually updates its methods and services. Currently, it coordinates some of its larger entries with Pfam-A and uses PSI-BLAST to cluster the remaining sequences in SWISS-PROT and TrEMBL. While only large entries have been scrutinized manually, the consistency of all families is assessed by computing a series of numerical measurements. The resulting families are represented as consensus sequences and gapped multiple alignments. Phylogenetic trees are computed from these alignments and used to display a family in overlapped subfamilies based on distances in the tree. Documentation consists of links to the protein sequence databases and to other protein family databases (PROSITE,.
