Vascular endothelial growth factor (VEGF) is a key regu-lator of angiogenesis and post-transcriptional regulation plays a major role in VEGF expression. Both the 5¢-and 3¢-UTR are required for VEGF post-transcriptional regu-lation but factors binding to functional sequences within the 5¢-UTR have not been fully characterized. We report here the identification of complexes, binding to theVEGF mRNA 5¢-and3¢-UTR, that contain cold shock domain (CSD) and polypyrimidine tract binding (PTB) RNA binding proteins. .
