Studies inknockoutmice support the involvement of alcohol dehydrogenases ADH1 and ADH4 in retinoid metabolism, althoughkineticswithretinoids arenotknown for themouse , a roleof alcohol dehydrogenase (ADH) in the eye retinoid interconversions cannot be ascertained due to the lack of information on the kinetics with 11-cis-retinoids. We report here the kinetics of human ADH1B1, ADH1B2, ADH4, and mouse ADH1 and ADH4 with all-trans-, 7-cis-, 9-cis-, 11-cis- and 13-cis-isomers of retinol and retinal
