Despitedecadesof investigation, theprimary siteof actionof the prototypical inducers of differentiation, dimethylsulfox-ide andhexamethylene bisacetamide (HMBA), has not been studies designed to analyzecis-acting elements responsible for induction of stage-specific globin genes, we discovered the capacity of HMBA and dimethyl-sulfoxide toenhance the expressionof transiently transfected reporter genes derived from globin and nonglobin gene promoters, prominently innonerythroid3T3Swiss cells
