The effects of protection of chylomicron remnants from oxidation on their uptake and induction of lipid accumula-tion in macrophages were investigated using chylomicron remnant-like particles (CRLPs) containing the lipophilic antioxidant drug, probucol, andmacrophages derived from thehumanmonocyte cell line, total lipidcontent of THP-1 macrophages was markedly higher (·) after 48 h of incubation of THP-1 macrophages with CRLPs containing probucol (pCRLPs) when compared to CRLPs without probucol, and this was because of increases in tri-acylglycerol (·) and cholesterol (·) levels, while cho-lesteryl ester concentrations were not significantly changed
