A novel hypoxically regulated intercellular junction protein (claudin-like protein of 24 kDa, CLP24) hasbeen identified that shows homology to the myelin protein 22/epithelial membrane protein 1/claudin family of cell junction proteins, which are involved in the modulation of paracellular per-meability. The CLP24 protein containsfour predicted transmembrane domains and a C-terminal protein–protein interaction domain. These domains are characteristic of the four transmembrane spanning (tetraspan) family of pro-teins, which includes myelin protein 22, and are involved in cell adhesion at tight, gap and adherens junctions
