A putative phosphoglycerate dehydrogenase (PGDH), which catalyzes the oxidation ofD-phosphoglycerate to 3-phosphohydroxypyruvate in the so-called phosphorylated serine metabolic pathway, from the enteric protozoan parasite Entamoeba histolytica was characterized. The E. histolyticaPGDH gene (EhPGDH) encodes a protein of 299 amino acids with a calculated molecular mass of kDa and an isoelectric point . EhPGDHshowed high homology to PGDH from bacteroides and another enteric protozoan ciliate,Entodinium caudatum. .
