The interaction between cell-adhesion molecules CD2 and CD58 is critical for an immune response. Modulation or inhibition of these interactions has been shown to be thera-peuticallyuseful. Synthetic 12-mer linear and cyclic peptides, and cyclic hexapeptides based on rat CD2 protein, were designed tomodulateCD2–CD58 interaction. The synthetic peptides effectively blocked the interaction between CD2– CD58 proteins as demonstrated by antibody binding, E-rosetting and heterotypic adhesion assays. .
