The red cell intercellular adhesion molecule-4 (ICAM-4) binds to different members of the integrin receptor families. Tobetterdefine the ICAM-4 integrinreceptor specificity, cell transfectants individually expressing various integrins were used to demonstrate thataLb2,aMb2,andaIIbb3(activated) bind specifically and dose dependently to the recombinant also showthat cell surface ICAM-4 interacts with the cell surface aVb3 integrin.