Thec-jun belongs to the family of proto-oncogenes and encodes for the protein Jun, a component of transcription factorAP-1 involved in regulation of the expression of genes indispensable for cell proliferation and differentiation. While the role ofc-junin the regulation of such genes has been well examined, the regulation ofc-junin proliferating cells is not fully understood. We have earlier reported that the)148 to)124 region ofc-junis involved in the positive regulation ofc-juntranscription, and interacts with a pos-itive regulatory factor (rat liver jun regulatory protein; RLjunRP) present in rat liver
