The effects of pesticide contamination on the metabolism of marine mol-luscs are poorly documented. We investigated the response of a marine bivalve, the Pacific oyster,Crassostrea gigas, using a suppression subtrac-tive hybridization method to identify up- and down-regulated genes after a 30-day exposure period to herbicides (a cocktail of atrazine, diuron and isoproturon, and to the single herbicide glyphosate). A total of 137 unique differentially expressed gene sequences was identified, as well as their asso-ciated physiological process