Its central theme was derived from a comprehensive essay entitled “Infectious History” that he published several years earlier in Science (Lederberg, 2000; reprinted as Appendix WO-1). Under the heading, “Evolving Metaphors of Infection: Teach War No More,” Lederberg argued that “[w]e should think of each host and its parasites as a superorganism with the respective genomes yoked into a chimera of sorts.”