Histologic observations support two mechanisms for permanent hair reduction: miniaturization of coarse hair follicles to vellus-like hair follicles, and destruction of the hair follicle with gran- ulomatous degeneration, leaving a fibrotic remnant. Clinically, both of these mechanisms produced reduction in hair. The study design used a fixed set of fluence-pulse-width combinations in each patient, regard- less of skin type. If skin type and color had been matched to appropriate fluences, the inci- dence of side effects could have been reduced. Epidermal damage was seen in 6% of cases. Textural change occurred in 3% of cases, where triple pulsing was used at the highest fluence. These.
