Many of the inorganic and aesthetic constituents evaluated in the Guidelines are known to be essential for life. Chromium, copper, fluoride, iodine, manganese, molybdenum, and selenium are essential elements in human nutrition; arsenic and nickel are considered by some researchers as essential elements. Of the aesthetic constituents, iron, chloride, calcium and magnesium (hardness), sodium and zinc are essential elements. A classification into "essential" and "toxic" elements is fraught with difficulties since as science advances, there is a constant shift of the elements from one group to the other. Toxicity is inherent in all elements, and is a.