Aspartate transcarbamylase from the hyperthermophilic archaeon Pyrococcus abyssi Insights into cooperative and allosteric mechanisms Sigrid Van Boxstael1, Dominique Maes2,3 and Raymond Cunin1 1 Erfelijkheidsleer en Microbiologie, Vrije Universiteit Brussel, Belgium 2 Ultrastructuur, Vrije Universiteit Brussel, Belgium 3 Vlaams Interuniversitair Instituut voor Biotechnologie, Belgium Keywords allostery; aspartate transcarbamylase; cooperativity; inhibition by analogues; Pyrococcus abyssi Correspondence R. Cunin, Erfelijkheidsleer en Microbiologie, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium Fax: 32 2 629 1473 Tel: 32 2 629 1341 E-mail: rcunin@ (Received 15 December 2004, revised 1 March 2005, accepted 22 March 2005) doi: Aspartate transcarbamylase (ATCase) (EC ) from the hyperthermophilic archaeon Pyrococcus abyssi was purified.
