The structures of MornigaM and the MornigaM–mannose complex have been determined at A˚ and A˚ resolution, respectively. Both struc-tures adopt the typical b-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbo-hydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure–function rela-tionships within the small group of Moraceae lectins
